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Regulation of Streptomyces development: reach for the sky!

Lookup NU author(s): Dr Dennis Claessen

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Abstract

Streptomyces coelicolor is characterized by a complex life cycle and serves as a model system for bacterial development. After a feeding substrate mycelium has been formed, this filamentous bacterium differentiates by forming aerial hyphae that septate into spores. The bld cascade regulates initiation of aerial growth, whereas the whi genes control spore formation. Recent findings indicate the existence of another regulatory pathway that operates after aerial hyphae have started to grow into the air, which we call the sky pathway. This pathway controls the expression of the chaplin and rodlin genes. These genes encode proteins that assemble into a rodlet layer that provides surface hydrophobicity to aerial hyphae and spores. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Claessen D, de Jong W, Dijkhuizen L, Wosten HAB

Publication type: Review

Publication status: Published

Journal: Trends in Microbiology

Year: 2006

Volume: 14

Issue: 7

Pages: 313-319

ISSN (print): 0966-842X

ISSN (electronic): 1878-4380

URL: http://dx.doi.org/10.1016/j.tim.2006.05.008

DOI: 10.1016/j.tim.2006.05.008

PubMed id: 16759865

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