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Mcm-2 and Ki-67 have limited potential in preoperative diagnosis of thyroid malignancy

Lookup NU author(s): Pallavi Mehrotra, Dr Sarah Johnson, Emerita Professor Janet WilsonORCiD, Dr Barry Davies, Professor Thomas Lennard


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OBJECTIVES: Minichromosome maintenance protein 2 (Mcm-2) is essential for DNA replication and serves as a useful biomarker of cell-cycle state in human tissue samples. Ki-67 is an established proliferation marker. Because Mcm-2 expression has not previously been assessed in thyroid tissue, the aim of this study was to assess the expression of both proteins in a range of thyroid lesions to determine their potential value as preoperative markers of thyroid malignancy. METHODS: Mcm-2 and Ki-67 protein expression were assessed by immunohistochemistry in formalin-fixed, paraffin-embedded thyroid tissues from 128 patients with histologic diagnoses of papillary carcinoma (n = 38), follicular carcinoma (n = 22), follicular adenoma (n = 33), and dominant nodules of multinodular goitre (n = 35). RESULTS: Mcm-2 and Ki-67-labeling indices (LIs) were both higher in follicular and papillary carcinomas than in follicular adenomas or dominant nodules. The Ki-67 LI discriminated better between follicular carcinomas and follicular adenomas (P < .0001) than Mcm-2 (P = .0273). However, the Mcm-2 and Ki-67 LIs overlapped widely between the four histologic groups, and the expression of these proteins was also noted to be heterogenous within these lesions. CONCLUSION: Neither Mcm-2 or Ki-67 can currently be reliably applied as preoperative markers to distinguish benign from malignant thyroid lesions. © 2006 The American Laryngological, Rhinological and Otological Society, Inc.

Publication metadata

Author(s): Mehrotra, P., Gonzalez, M., Johnson, S., Coleman, N., Wilson, J., Davies, B., Lennard, T.W.J.

Publication type: Article

Publication status: Published

Journal: Laryngoscope

Year: 2006

Volume: 116

Issue: 8

Pages: 1434-1438

Print publication date: 01/08/2006

ISSN (print): 0023-852X

ISSN (electronic): 1091-756X


DOI: 10.1097/01.mlg.0000225931.59644.93

PubMed id: 16885749


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Funder referenceFunder name
MC_U105359878Medical Research Council