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Lookup NU author(s): Dr Sally Parry, Rachel Stansfield, Professor Roger Barton, Dr Mark Welfare
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Postinfectious functional gastrointestinal disorders (FGIDs) may not be specific to gastroenteritis. This pilot study aimed to ascertain the 3- and 6-month incidence of functional gut disorders in people with non-gastrointestinal (GI) infection, gastroenteritis and healthy controls. This was a prospective study of three cohorts recruited from hospital (non-GI infections) and the community (others). FGIDs were diagnosed using self-completed Rome II modular questionnaires administered at baseline, 3 and 6 months. Thirty-six subjects with non-GI infection, 219 healthy subjects and 108 with bacterial gastroenteritis participated. No difference in incidence of FGID was detected between the GI and non-GI infection cohorts. Any FGID was more frequent in people who had a non-GI infection than in controls at both 3 [odds ratio: 4.34 (95% CI: 3.60-16.45)] and 6 months [4.76 (4.42-27.92)]. Irritable bowel syndrome (IBS) alone was more frequent in people with non-GI infections than in controls at 3 months (6.12 [1.30-29.12]) but did not quite reach statistical significance at 6 months (4.58 [0.79-26.46]). Our findings were unexpected. Postinfectious FGIDs may be related to non-GI and GI infection, although not all potential biases were controlled in study design. Further studies need to explore these preliminary findings and, if confirmed, the underlying mechanisms. © 2006 The Authors.
Author(s): Mckeown ES, Parry SD, Stansfield R, Barton JR, Welfare MR
Publication type: Article
Publication status: Published
Journal: Neurogastroenterology and Motility
Year: 2006
Volume: 18
Issue: 9
Pages: 839-843
ISSN (print): 1350-1925
ISSN (electronic): 1365-2982
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1111/j.1365-2982.2006.00821.x
DOI: 10.1111/j.1365-2982.2006.00821.x
PubMed id: 16918763
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