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Lookup NU author(s): Dr Tryfonia Mainou-Fowler, Dr Brian Angus, Professor Stephen Proctor, Dr Penelope Taylor, Dr Katrina Wood
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There is little information to date regarding the role of angiogenesis in Hodgkin lymphoma (HL). The present study examines micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial growth factor (PdEGF) in lymph node biopsies of patients with HL at presentation and relapse. Using immunohistochemistry, the degree of new blood vessel formation and the expression of VEGF and PdEGF was assessed in Hodgkin-rich tissue. The micro-vessel density (MVD) increased with disease progression in seven out of 11 cases. Expression of VEGF was observed in endothelial cells (EC) of some micro-vessels and also in follicular dendritic cells. The Hodgkin/Reed-Sternberg (H-RS) cells as well as the inflammatory lymphocytes were negative for VEGF. Cytoplasmic or cytoplasmic and nuclear expression of PdEGF by the H-RS cells was observed in five of the 11 presentation cases. The expression of PdEGF increased with disease progression in seven cases. In conclusion, Hodgkin tissue shows prominent vascularization. The increased MVD and PdEGF expression with disease progression merits further investigation. © 2006 Taylor & Francis.
Author(s): Mainou-Fowler, T., Angus, B., Miller, S., Proctor, S. J., Taylor, P. R. A., Wood, K.
Publication type: Article
Publication status: Published
Journal: Leukemia and Lymphoma
Year: 2006
Volume: 47
Issue: 2
Pages: 223-230
Print publication date: 01/02/2006
ISSN (print): 1042-8194
ISSN (electronic): 1029-2403
URL: http://dx.doi.org/10.1080/01674820500305838
DOI: 10.1080/01674820500305838
PubMed id: 16321851
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