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A model of long-term metabolic progression of type 2 diabetes mellitus for evaluating treatment strategies

Lookup NU author(s): Emeritus Professor Philip Home


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Aim: To develop a novel metabolic computer model of the natural lifetime progression of type 2 diabetes that generates dynamic risk factor trajectories consistent with prespecified lifetime therapeutic strategies, in order to enhance the long-term economic and outcome modelling of type 2 diabetes and its complications. Methods: The main model drivers of progressive disease were changes in insulin sensitivity and islet β-cell function derived from an analysis of follow-up results from the Belfast Diet Study. These were related to clinical measures through an adaptation of the homeostasis model assessment. Established causal relationships estimating body mass index, lipids and blood pressure from measures of glycaemia and plasma insulin were calibrated using Third National Health and Nutrition Examination Survey (USA) data, standardizing for age, sex, ethnicity and smoking. The effects of individual interventions were calibrated using published trial evidence, in line with the current understanding of the main modes of action of each agent. Results: A comparison of the effects of common therapies using the model showed both similarities and differences. Large improvements in glycaemic control from lifestyle modifications, further enhanced by oral glucose-lowering drugs or insulin, were reproduced. Projections comparing lifetime therapeutic strategies suggest that simple guidelines may not always be valid. Conclusion: This novel mathematical model using evidence from the long-term natural history of type 2 diabetes is able to project the expected effects of various antihyperglycaemic therapies. Coupled with an economic model, this metabolic model may provide a mechanism for healthcare professionals and policymakers to evaluate different long-term strategies for the management of type 2 diabetes. © 2006 Adis Data Information BV. All rights reserved.

Publication metadata

Author(s): Bagust A, Evans M, Beale S, Home PD, Perry AS, Stewart M

Publication type: Article

Publication status: Published

Journal: PharmacoEconomics

Year: 2006

Volume: 24

Issue: Suppl. 1

Pages: 5-19

Print publication date: 01/01/2006

ISSN (print): 1170-7690

ISSN (electronic): 1179-2027

Publisher: Adis International Ltd.


DOI: 10.2165/00019053-200624001-00002

PubMed id: 16800159


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