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Staufen- and FMRP-Containing Neuronal RNPs Are Structurally and Functionally Related to Somatic P Bodies

Lookup NU author(s): Dr Sarah Newbury

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Abstract

Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the role and composition of ribonucleoprotein (RNP) particles that mediate transport and translation of neuronal RNAs. Here, we show that staufen- and FMRP-containing RNPs in Drosophila neurons contain proteins also present in somatic "P bodies," including the RNA-degradative enzymes Dcp1p and Xrn1p/Pacman and crucial components of miRNA (argonaute), NMD (Upf1p), and general translational repression (Dhh1p/Me31B) pathways. Drosophila Me31B is shown to participate (1) with an FMRP-associated, P body protein (Scd6p/trailer hitch) in FMRP-driven, argonaute-dependent translational repression in developing eye imaginal discs; (2) in dendritic elaboration of larval sensory neurons; and (3) in bantam miRNA-mediated translational repression in wing imaginal discs. These results argue for a conserved mechanism of translational control critical to neuronal function and open up new experimental avenues for understanding the regulation of mRNA function within neurons. © 2006 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Barbee SA, Estes PS, Cziko A-M, Hillebrand J, Luedeman RA, Coller JM, Johnson N, Howlett IC, Geng C, Ueda R, Brand AH, Newbury SF, Wilhelm JE, Levine RB, Nakamura A, Parker R, Ramaswami M

Publication type: Article

Publication status: Published

Journal: Neuron

Year: 2006

Volume: 52

Issue: 6

Pages: 997-1009

ISSN (print): 0896-6273

ISSN (electronic): 1097-4199

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.neuron.2006.10.028

DOI: 10.1016/j.neuron.2006.10.028

PubMed id: 17178403

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