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Staufen- and FMRP-Containing Neuronal RNPs Are Structurally and Functionally Related to Somatic P Bodies

Lookup NU author(s): Dr Sarah Newbury

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Abstract

Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the role and composition of ribonucleoprotein (RNP) particles that mediate transport and translation of neuronal RNAs. Here, we show that staufen- and FMRP-containing RNPs in Drosophila neurons contain proteins also present in somatic "P bodies," including the RNA-degradative enzymes Dcp1p and Xrn1p/Pacman and crucial components of miRNA (argonaute), NMD (Upf1p), and general translational repression (Dhh1p/Me31B) pathways. Drosophila Me31B is shown to participate (1) with an FMRP-associated, P body protein (Scd6p/trailer hitch) in FMRP-driven, argonaute-dependent translational repression in developing eye imaginal discs; (2) in dendritic elaboration of larval sensory neurons; and (3) in bantam miRNA-mediated translational repression in wing imaginal discs. These results argue for a conserved mechanism of translational control critical to neuronal function and open up new experimental avenues for understanding the regulation of mRNA function within neurons. © 2006 Elsevier Inc. All rights reserved.


Publication metadata

Author(s): Barbee SA, Estes PS, Cziko A-M, Hillebrand J, Luedeman RA, Coller JM, Johnson N, Howlett IC, Geng C, Ueda R, Brand AH, Newbury SF, Wilhelm JE, Levine RB, Nakamura A, Parker R, Ramaswami M

Publication type: Article

Publication status: Published

Journal: Neuron

Year: 2006

Volume: 52

Issue: 6

Pages: 997-1009

ISSN (print): 0896-6273

ISSN (electronic): 1097-4199

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.neuron.2006.10.028

DOI: 10.1016/j.neuron.2006.10.028

PubMed id: 17178403


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Funding

Funder referenceFunder name
BB/C005163/1Biotechnology and Biological Sciences Research Council
DA15495NIDA NIH HHS
DA17749NIDA NIH HHS
G0300072Medical Research Council
GM54409NIGMS NIH HHS
K02 DA017749NIDA NIH HHS
R01 DA015495NIDA NIH HHS
R01 GM054409NIGMS NIH HHS
R37 GM045443NIGMS NIH HHS

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