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Cellular functions of TIP60

Lookup NU author(s): Dr Vasileia Sapountzi, Dr Ian Logan, Professor Craig Robson


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TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated intensively. Recent data suggest that TIP60 has more divergent functions than originally thought and roles for TIP60 in many processes, such as cellular signalling, DNA damage repair, cell cycle and checkpoint control and apoptosis are emerging. TIP60 is a tightly regulated transcriptional coregulator, acting in a large multiprotein complex for a range of transcription factors including androgen receptor, Myc, STAT3, NF-κB, E2F1 and p53. This usually involves recruitment of TIP60 acetyltransferase activities to chromatin. Additionally, in response to DNA double strand breaks, TIP60 is recruited to DNA lesions where it participates both in the initial as well as the final stages of repair. Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Sapountzi, V., Logan, I. R., Robson, C. N.

Publication type: Review

Publication status: Published

Journal: International Journal of Biochemistry & Cell Biology

Year: 2006

Volume: 38

Issue: 9

Pages: 1496-1509

Print publication date: 01/03/2006

ISSN (print): 1357-2725

ISSN (electronic): 1878-5875


DOI: 10.1016/j.biocel.2006.03.003

PubMed id: 16698308