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Nutritional modulation of ageing: Genomic and epigenetic approaches

Lookup NU author(s): Professor John Mathers


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Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understanding the molecular mechanisms by which nutrition affects ageing. To date, transcriptional profiling techniques have been applied in studies of the mode of action of energy (caloric) restriction. Two further areas which appear to be particularly promising are (i) nutritional modulation of DNA damage and repair and (ii) nutritional modulation of epigenetic markings. Epigenetic-mediated changes in gene expression in response to dietary and other lifestyle exposures appear to be a major molecular mechanism linking environmental factors with the genome with consequences for cell function and health throughout the life course. © 2006 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Mathers JC

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2006

Volume: 127

Issue: 6

Pages: 584-589

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier


DOI: 10.1016/j.mad.2006.01.018

PubMed id: 16513160


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