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Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance

Lookup NU author(s): Professor Nigel Unwin, Professor Martin White, Professor John Mathers, Emeritus Professor Sir George Sir George Alberti


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Aim: To evaluate the effectiveness of lifestyle interventions in people with impaired glucose tolerance (IGT). Methods: Participants with IGT (n = 78), diagnosed on two consecutive oral glucose tolerance tests (OGTTs), were randomly assigned to a 2-year lifestyle intervention or to a control group. Main outcome measures were changes from baseline in: nutrient intake; physical activity; anthropometry, glucose tolerance and insulin sensitivity. Measurements were repeated at 6, 12 and 24 months follow-up. Results: After 24 months follow-up, there was a significant fall in total fat consumption (difference in change between groups (Δ intervention - Δ control) = -17.9, 95% confidence interval (CI) -33.6 to -2.1 g/day) as a result of the intervention. Body mass was significantly lower in the intervention group compared with controls after 6 months (-1.6, 95% CI -2.9 to -0.4 kg) and 24 months (-3.3, 95% CI -5.7 to -0.89 kg). Whole body insulin sensitivity, assessed by the short insulin tolerance test (ITT), improved after 12 months in the intervention group (0.52, 95% CI 0.15-0.89%/min). Conclusions: These findings complement the findings of the Finnish Diabetes Prevention Study and the American Diabetes Prevention Study, both of which tested intensive interventions, by showing that pragmatic lifestyle interventions result in improvements in obesity and whole body insulin sensitivity in individuals with IGT, without change in other cardiovascular risk factors. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Oldroyd JC, Unwin NC, White M, Mathers JC, Alberti KGMM

Publication type: Article

Publication status: Published

Journal: Diabetes Research and Clinical Practice

Year: 2006

Volume: 72

Issue: 2

Pages: 117-127

Print publication date: 01/05/2006

ISSN (print): 0168-8227

ISSN (electronic): 1872-8227

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.diabres.2005.09.018

PubMed id: 16297488


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