Toggle Main Menu Toggle Search

Open Access padlockePrints

Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease

Lookup NU author(s): David Rawlings, Dr David WalshawORCiD, Emeritus Professor Roger Francis, Dr Nicholas Thompson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Aim: To determine the prevalence of osteoporosis in a cohort of patients with Crohn's disease (CD) and to identify the relative significance of risk factors for osteoporosis. Methods: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). Results: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. Conclusion: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for the bone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. © 2006 The WJG Press. All rights reserved.

Publication metadata

Author(s): Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP

Publication type: Article

Publication status: Published

Journal: World Journal of Gastroenterology

Year: 2006

Volume: 12

Issue: 35

Pages: 5680-5686

ISSN (print): 1007-9327

ISSN (electronic): 1009-3079

Publisher: WJG Press