Toggle Main Menu Toggle Search

Open Access padlockePrints

A proteomic analysis of Streptomyces coelicolor programmed cell death

Lookup NU author(s): Dr Ulrike Mader, Professor Bernard Connolly


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Programmed cell death (PCD) is an active cellular suicide that occurs in eukaryotes and bacteria in response to both abiotic and biotic stresses. In contrast to eukaryotic apoptosis, little is known about the molecular machinery that regulates bacterial PCD. In a previous work, we described the existence of PCD phenomena in Streptomyces (Manteca et al., Res. Microbiol. 2006, 157, 143-152). In the present study, we performed a proteomic analysis of PCD in Streptomyces coelicolor, for which we developed a system to obtain dead and live cell-enriched samples. PCD in this filamentous bacterium is accompanied by the appearance of enzymes involved in the degradation of cellular macromolecules, regulatory proteins, and stress-induced proteins. We argue that some of these proteins have specific functions in the PCD pathway and putative roles for the identified proteins have been proposed. The increased amounts of several antioxidant proteins suggest oxidative stress as either the cause or consequence of the cell death. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication metadata

Author(s): Manteca A, Mader U, Connolly BA, Sanchez J

Publication type: Article

Publication status: Published

Journal: Proteomics

Year: 2006

Volume: 6

Issue: 22

Pages: 6008-6022

ISSN (print): 1615-9853

ISSN (electronic): 1615-9861

Publisher: Wiley - VCH Verlag GmbH & Co. KGaA


DOI: 10.1002/pmic.200600147

PubMed id: 17051639


Altmetrics provided by Altmetric