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Lookup NU author(s): Dr Ulrike Mader, Professor Bernard Connolly
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Programmed cell death (PCD) is an active cellular suicide that occurs in eukaryotes and bacteria in response to both abiotic and biotic stresses. In contrast to eukaryotic apoptosis, little is known about the molecular machinery that regulates bacterial PCD. In a previous work, we described the existence of PCD phenomena in Streptomyces (Manteca et al., Res. Microbiol. 2006, 157, 143-152). In the present study, we performed a proteomic analysis of PCD in Streptomyces coelicolor, for which we developed a system to obtain dead and live cell-enriched samples. PCD in this filamentous bacterium is accompanied by the appearance of enzymes involved in the degradation of cellular macromolecules, regulatory proteins, and stress-induced proteins. We argue that some of these proteins have specific functions in the PCD pathway and putative roles for the identified proteins have been proposed. The increased amounts of several antioxidant proteins suggest oxidative stress as either the cause or consequence of the cell death. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Author(s): Manteca A, Mader U, Connolly BA, Sanchez J
Publication type: Article
Publication status: Published
Journal: Proteomics
Year: 2006
Volume: 6
Issue: 22
Pages: 6008-6022
ISSN (print): 1615-9853
ISSN (electronic): 1615-9861
Publisher: Wiley - VCH Verlag GmbH & Co. KGaA
URL: http://dx.doi.org/10.1002/pmic.200600147
DOI: 10.1002/pmic.200600147
PubMed id: 17051639
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