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Cullen's sign and massive ovarian enlargement secondary to primary hypothyroidism in a patient with a normal FSH receptor

Lookup NU author(s): Professor Timothy Cheetham


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Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophic thyroiditis who presented with abdominal pain and distension is reported. She was noted to have bruising in the vicinity of the umbilicus (Cullen's sign). She had pronounced ovarian enlargement on ultrasonography and it was hypothesised that this profound phenotype might reflect an abnormal FSH receptor. However sequencing of the FSH receptor was normal. The ovarian enlargement resolved with thyroxine replacement. Physicians and surgeons should consider longstanding hypothyroidism in patients presenting with Cullen's sign.

Publication metadata

Author(s): Sultan A, Velaga MR, Fleet M, Cheetham T

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2006

Volume: 91

Issue: 6

Pages: 509-510

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group


DOI: 10.1136/adc.2005.088443

PubMed id: 16714722


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