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The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3

Lookup NU author(s): Dr Amanda Greenall


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PEA3 is a member of a subfamily of ETS domain transcription factors which is regulated by a number of signaling cascades, including the mitogen-activated protein (MAP) kinase pathways. PEA3 activates gene expression and is thought to play an important role in promoting tumor metastasis and also in neuronal development. Here, we have identified the LIM domain protein LPP as a novel coregulatory binding partner for PEA3. LPP has intrinsic transactivation capacity, forms a complex with PEA3, and is found associated with PEA3-regulated promoters. By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3. LPP can also functionally interact in a similar manner with the related family member ER81. Thus, we have uncovered a novel nuclear function for the LIM domain protein LPP as a transcriptional coactivator. As LPP continually shuttles between the cell periphery and the nucleus, it represents a potential novel link between cell surface events and changes in gene expression. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Publication metadata

Author(s): Guo B, Sallis RE, Greenall A, Petit MMR, Jansen E, Young L, Van De Ven WJM, Sharrocks AD

Publication type: Article

Publication status: Published

Journal: Molecular and Cellular Biology

Year: 2006

Volume: 26

Issue: 12

Pages: 4529-4538

ISSN (print): 0270-7306

ISSN (electronic): 1067-8824

Publisher: American Society for Microbiology


DOI: 10.1128/MCB.01667-05

PubMed id: 16738319


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