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Lookup NU author(s): Dr Amanda Greenall
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PEA3 is a member of a subfamily of ETS domain transcription factors which is regulated by a number of signaling cascades, including the mitogen-activated protein (MAP) kinase pathways. PEA3 activates gene expression and is thought to play an important role in promoting tumor metastasis and also in neuronal development. Here, we have identified the LIM domain protein LPP as a novel coregulatory binding partner for PEA3. LPP has intrinsic transactivation capacity, forms a complex with PEA3, and is found associated with PEA3-regulated promoters. By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3. LPP can also functionally interact in a similar manner with the related family member ER81. Thus, we have uncovered a novel nuclear function for the LIM domain protein LPP as a transcriptional coactivator. As LPP continually shuttles between the cell periphery and the nucleus, it represents a potential novel link between cell surface events and changes in gene expression. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Author(s): Guo B, Sallis RE, Greenall A, Petit MMR, Jansen E, Young L, Van De Ven WJM, Sharrocks AD
Publication type: Article
Publication status: Published
Journal: Molecular and Cellular Biology
ISSN (print): 0270-7306
ISSN (electronic): 1067-8824
Publisher: American Society for Microbiology
PubMed id: 16738319
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