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Lookup NU author(s): Dr Nicholas Allenby, Dr Carys WattsORCiD, Dr Georg Homuth, Dr Zoltan Pragai, Professor Anil Wipat, Emeritus Professor Alan Ward, Professor Colin Harwood
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Bacillus subtilis produces and exports a peptide sporulation killing factor (SkfA) that induces lysis of sibling cells. skfA is part of the skf operon (skfA-H), which is responsible for immunity to SkfA, as well as for production and export of SkfA. Here we report that transcription of skfA is markedly induced when cells of B. subtilis are subjected to phosphate starvation. The role of PhoP in regulation of the skf operon was confirmed by in vitro gel shift assays, which showed that this operon is a new member of the PhoP regulon. A putative stem-loop structure in the skfA-skfB intergenic region is proposed to act as a stabilizer of an skfA-specific transcript. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Author(s): Allenby NEE, Watts CA, Homuth G, Pragai Z, Wipat A, Ward AC, Harwood CR
Publication type: Article
Publication status: Published
Journal: Journal of Bacteriology
Year: 2006
Volume: 188
Issue: 14
Pages: 5299-5303
ISSN (print): 0021-9193
ISSN (electronic): 1067-8832
Publisher: American Society for Microbiology
URL: http://dx.doi.org/10.1128/JB.00084-06
DOI: 10.1128/JB.00084-06
PubMed id: 16816204
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