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Reconciling the mutation-selection balance model with the schizotypy-creativity connection

Lookup NU author(s): Professor Daniel Nettle



Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed. © 2006 Cambridge University Press.

Publication metadata

Author(s): Nettle D

Publication type: Article

Publication status: Published

Journal: Behavioral and Brain Sciences

Year: 2006

Volume: 29

Issue: 4

Pages: 418-418

Date deposited: 17/09/2010

ISSN (print): 0140-525X

ISSN (electronic): 1469-1825

Publisher: Cambridge University Press


DOI: 10.1017/S0140525X06359092


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