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Lookup NU author(s): Professor Peter Thomson,
Professor Richard Boys
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The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1 mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N2O/O2 and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P < 0.001), an overall significant reduction in recovery time (P < 0.001) and a significant improvement in co-operation (P < 0.01) and arterial oxygen saturation (P < 0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation. © 2005 International Association of Oral and Maxillofacial Surgeons.
Author(s): Venchard GR, Thomson PJ, Boys R
Publication type: Article
Publication status: Published
Journal: International Journal of Oral and Maxillofacial Surgery
ISSN (print): 0901-5027
ISSN (electronic): 1399-0020
Publisher: Churchill Livingstone
PubMed id: 16442264
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