Toggle Main Menu Toggle Search

Open Access padlockePrints

Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial

Lookup NU author(s): Professor Peter Thomson, Professor Richard Boys


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1 mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N2O/O2 and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P < 0.001), an overall significant reduction in recovery time (P < 0.001) and a significant improvement in co-operation (P < 0.01) and arterial oxygen saturation (P < 0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation. © 2005 International Association of Oral and Maxillofacial Surgeons.

Publication metadata

Author(s): Venchard GR, Thomson PJ, Boys R

Publication type: Article

Publication status: Published

Journal: International Journal of Oral and Maxillofacial Surgery

Year: 2006

Volume: 35

Issue: 6

Pages: 522-527

ISSN (print): 0901-5027

ISSN (electronic): 1399-0020

Publisher: Churchill Livingstone


DOI: 10.1016/j.ijom.2005.11.003

PubMed id: 16442264


Altmetrics provided by Altmetric