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Comparison of the effect of sodium hyaluronate (Ophthalin®) and hydroxypropylmethylcellulose (HPMC-Ophtal®) on corneal endothelium, central corneal thickness, and intraocular pressure after phacoemulsification

Lookup NU author(s): Neeta Ray-Chaudhuri, Professor Francisco FigueiredoORCiD


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PURPOSE. To prospectively evaluate the effects of 2% hydroxypropyl- methylcellulose (HPMC-Ophtal®) and sodium hyaluronate 1% (Ophthalin®) on intraocular pressure, corneal thickness, and endothelial cell loss in small incision cataract surgery with implant. METHODS. A total of 110 patients undergoing routine phacoemulsification with implant received either 2% hydroxypropylmethylcellulose or sodium hyaluronate 1% as ophthalmic viscosurgical device. Pre- and postoperative slit lamp examination, intraocular pressure measurement (preoperatively and at 1-4 hours, 1 day, and 7 days postoperatively), ultrasonic pachymetry (preoperatively and at 1 week, 4-6 weeks, and 12 weeks postoperatively), and corneal endothelial cell count (preoperatively and 12 weeks postoperatively) were performed. Data were analyzed using two-way analysis of variance. RESULTS. All measurements were comparable between the two groups preoperatively. Intraocular pressure was significantly lower in the Ophthalin® group at 1 day postoperatively, while no significant difference was found between the two groups on the 1-4 hours and 7 days examination. The central corneal thickness was not significantly different between the two groups at any postoperative visit. However, the mean cell density demonstrated a significant fall of 11.76% for Ophthalin® and 4.27% for HPMC-Ophtal® at 12 weeks postoperatively, the difference between the two being significant (p=0.009). CONCLUSIONS. 2% Hydroxypropylmethylcellulose, compared with sodium hyaluronate 1%, is superior in protecting the corneal endothelial cells, has the same effect on central corneal thickness, and is associated with slightly higher intraocular pressure 1 day postoperatively. It compares favorably with sodium hyaluronate 1% and can be used as an effective and cheaper alternative in routine small incision cataract surgery with implant. © Wichtig Editore, 2006.

Publication metadata

Author(s): Ray-Chaudhuri N, Voros GM, Sutherland S, Figueiredo FC

Publication type: Article

Publication status: Published

Journal: European Journal of Ophthalmology

Year: 2006

Volume: 16

Issue: 2

Pages: 239-246

ISSN (print): 1120-6721

ISSN (electronic): 1724-6016

Publisher: Wichtig Editore Srl

PubMed id: 16703541