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Progressive depletion of mtDNA in mitochondrial myopathy

Lookup NU author(s): Dr Steve Durham, Emeritus Professor Doug Turnbull, Professor Patrick Chinnery


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The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications. Copyright © 2006 by AAN Enterprises, Inc.

Publication metadata

Author(s): Durham SE, Brown DT, Turnbull DM, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2006

Volume: 67

Issue: 3

Pages: 502-504

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1212/01.wnl.0000227961.55640.2f

PubMed id: 16894115


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Funder referenceFunder name
074454Wellcome Trust