Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Vang-like 2 and noncanonical Wnt signaling in outflow tract development

Lookup NU author(s): Professor Deborah HendersonORCiD, Dr Helen PhillipsORCiD, Dr Bill ChaudhryORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Despite rapid advances in cardiovascular developmental genetics, the precise morphogenetic processes that coordinate heart development, and the genes and signaling pathways that regulate them remain unclear. In this review, we describe a highly conserved signaling pathway, the noncanonical Wnt (planar cell polarity) pathway, and its relationship to cardiovascular development and congenital heart defects. This pathway regulates cell polarity and polarized cell movements in a variety of contexts. Mutations in several genes in this pathway and specifically in the Vang-like 2 (Vangl2) (strabismus) gene, result in abnormalities in the remodeling of the outflow tract and, ultimately, in the cardiac alignment defect double-outlet right ventricle. Polarized cell migration of cardiomyocytes into the outflow tract cushions is inhibited when Vangl2 function is disturbed, suggesting that the noncanonical Wnt pathway may regulate this aspect of outflow tract remodeling. These studies suggest that mutations in Vangl2 and other components of the noncanonical Wnt pathway, may be candidates for causing congenital outflow tract defects in humans. © 2006, Elsevier Inc.

Publication metadata

Author(s): Henderson DJ, Phillips HM, Chaudhry B

Publication type: Review

Publication status: Published

Journal: Trends in Cardiovascular Medicine

Year: 2006

Volume: 16

Issue: 2

Pages: 38-45

ISSN (print): 1050-1738

ISSN (electronic): 1873-2615

URL: http://dx.doi.org/10.1016/j.tcm.2005.11.005

DOI: 10.1016/j.tcm.2005.11.005

PubMed id: 16473760

Share