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Unbalanced alternative splicing and its significance in cancer

Lookup NU author(s): Dr Julian Venables

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Abstract

Alternative pre-mRNA splicing leads to distinct products of gene expression in development and disease. Antagonistic splice variants of genes involved in differentiation, apoptosis, invasion and metastasis often exist in a delicate equilibrium that is found to be perturbed in tumours. In several recent examples, splice variants that are overexpressed in cancer are expressed as hyperoncogenic proteins, which often correlate with poor prognosis, thus suggesting improved diagnosis and follow up treatment. Global gene expression technologies are just beginning to decipher the interplay between alternatively spliced isoforms and protein-splicing factors that will lead to identification of the mutations in these trans-acting factors responsible for pathogenic alternative splicing in cancer. © 2006 Wiley Periodicals, Inc.

Publication metadata

Author(s): Venables JP

Publication type: Review

Publication status: Published

Journal: BioEssays

Year: 2006

Volume: 28

Issue: 4

Pages: 378-386

ISSN (print): 0265-9247

ISSN (electronic): 1521-1878

URL: http://dx.doi.org/10.1002/bies.20390

DOI: 10.1002/bies.20390

PubMed id: 16547952

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