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A GABAergic component in the commissure of the inferior colliculus in rat

Lookup NU author(s): Professor Adrian ReesORCiD


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The commissure of the inferior colliculus is significant as the final point of interconnection between homologous structures on the two sides of the auditory pathway at the subcortical level. The presence of excitatory fibres is well established in this tract, but the existence of an inhibitory component is controversial. Using rats, we injected biotinylated dextran amine into the inferior colliculus on one side to retrogradely label cells projecting through the commissure from the contralateral inferior colliculus. Immunocytochemistry for γ-amino-n-butyric acid in neighbouring semithin sections revealed that 20% of biotinylated dextran amine cell profiles were also labelled for γ-amino-n-butyric acid. We conclude that monosynaptic inhibitory connections contribute to the inhibition observed in the contralateral inferior colliculus in functional studies of the commissural projection. © 2006 Lippincott Williams & Wilkins.

Publication metadata

Author(s): Hernandez O, Rees A, Malmierca MS

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 2006

Volume: 17

Issue: 15

Pages: 1611-1614

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/


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