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Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease

Lookup NU author(s): Professor David Burn, Dr Liesl Allcock, Dr John Davison, Professor Patrick Chinnery


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A genetic susceptibility to depression in PD, acting via the serotonergic system, has been suggested. We examined the influence of allelic variation (L/S) in a functional polymorphism in the serotonin transporter (5-HTTLPR) gene upon mood in 108 PD patients and 82 controls. Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Burn DJ, Tiangyou W, Allcock LM, Davison J, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Parkinsonism & Related Disorders

Year: 2006

Volume: 12

Issue: 3

Pages: 139-141

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier


DOI: 10.1016/j.parkreldis.2005.11.005

PubMed id: 16459126


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