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Physics-based multiplicative scatter correction approaches for improving the performance of calibration models

Lookup NU author(s): Dr Suresh Thennadil


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Light scattering effects pose a major problem in the estimation of chemical properties of particulate systems such as blood, tissue, and pharmaceutical solids. Recently, Martens et al. proposed an extended multiplicative signal correction (EMSC) approach where light-scattering effects were taken into account in an empirical manner. It is possible to include causal, first-principles mathematical models based on the physics of light scattering into the EMSC framework. This could lead to significant improvements in the separation of absorption and scattering effects. A preconditioning step prior to application of EMSC, whereby a transformation based on the physics of light scattering is used to convert the spectra into a form where the absorption and scattering effects are separable (an underlying assumption of EMSC), is proposed. Results indicate that the transformation followed by EMSC gives better calibration models than the direct application of EMSC to the absorbance spectra. © 2006 Society for Applied Sptctroscopy.

Publication metadata

Author(s): Thennadil SN, Martens H, Kohler A

Publication type: Article

Publication status: Published

Journal: Applied Spectroscopy

Year: 2006

Volume: 60

Issue: 3

Pages: 315-321

ISSN (print): 0003-7028

ISSN (electronic): 1943-3530

Publisher: Society for Applied Spectroscopy


DOI: 10.1366/000370206776342535

PubMed id: 16608575


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