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Lookup NU author(s): Dr Salman Razvi,
Dr Bijayeswar Vaidya,
Dr Petros Perros,
Professor Simon Pearce
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Block-replace and titration antithyroid drug regimens both give similar rates of medium- to long-term remission of hyperthyroid Graves' disease. Recent meta-analysis, however, has suggested that titration regimens may be preferable owing to a higher rate of adverse events seen in the block-replace arms of published comparative studies. This article critically re-evaluates the evidence upon which these meta-analyses were based. We suggest that there is little objective evidence that is pertinent to current clinical practice to separate block-replace from titration antithyroid drug regimens and that both remain satisfactory approaches to the medical management of hyperthyroid Graves' disease. © 2006 Society of the European Journal of Endocrinology.
Author(s): Razvi S, Vaidya B, Perros P, Pearce SHS
Publication type: Article
Publication status: Published
Journal: European Journal of Endocrinology
ISSN (print): 0804-4643
ISSN (electronic): 1479-683X
Publisher: BioScientifica Ltd.
PubMed id: 16728536
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