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What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves' disease

Lookup NU author(s): Dr Salman Razvi, Dr Bijayeswar Vaidya, Dr Petros Perros, Professor Simon PearceORCiD


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Block-replace and titration antithyroid drug regimens both give similar rates of medium- to long-term remission of hyperthyroid Graves' disease. Recent meta-analysis, however, has suggested that titration regimens may be preferable owing to a higher rate of adverse events seen in the block-replace arms of published comparative studies. This article critically re-evaluates the evidence upon which these meta-analyses were based. We suggest that there is little objective evidence that is pertinent to current clinical practice to separate block-replace from titration antithyroid drug regimens and that both remain satisfactory approaches to the medical management of hyperthyroid Graves' disease. © 2006 Society of the European Journal of Endocrinology.

Publication metadata

Author(s): Razvi S, Vaidya B, Perros P, Pearce SHS

Publication type: Article

Publication status: Published

Journal: European Journal of Endocrinology

Year: 2006

Volume: 154

Issue: 6

Pages: 783-786

ISSN (print): 0804-4643

ISSN (electronic): 1479-683X

Publisher: BioScientifica Ltd.


DOI: 10.1530/eje.1.02169

PubMed id: 16728536


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