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The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration

Lookup NU author(s): Dr Anita Nolan, Emeritus Professor Robin Seymour


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Background: The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) preparation (0.2%) in the management of recurrent aphthous ulceration (RAU). Methods: One hundred and twenty patients with RAU participated in a randomized, placebo controlled, double-blind trial to evaluate the efficacy of the topical HA and preparation. Outcome measures include soreness relief on immediate application (recorded over 60 min). Thereafter, patients completed a log diary recording soreness from the ulcers, occurrence of new ulcers and ulcer duration. Results: Both topical HA and placebo resulted in a significant reduction in ulcer soreness following immediate application (P = 0.0004). Throughout the rest of the investigation period, there was no significant differences (P > 0.05) between the treatments for reducing soreness. Patients treated with topical HA recorded few ulcers on day 5 of the investigation than those treated with placebo (P < 0.001). Likewise, the occurrence of new ulcers was lower in the HA treated group on day 4 when compared with placebo (P = 0.047). Conclusion: Topical HA (0.2%) may be of benefit in the management of RAU. Immediate reduction of symptoms appears to be a barrier effect. © Blackwell Munksgaard 2006. All rights reserved.

Publication metadata

Author(s): Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA

Publication type: Article

Publication status: Published

Journal: Journal of Oral Pathology and Medicine

Year: 2006

Volume: 35

Issue: 8

Pages: 461-465

ISSN (print): 0904-2512

ISSN (electronic): 1600-0714

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1600-0714.2006.00433.x

PubMed id: 16918596


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