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Different polyketide folding modes converge to an identical molecular architecture

Lookup NU author(s): Dr Gail Payne, Amanda Jones, Professor Michael Goodfellow


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Metabolic diversity is being studied intensively by evolutionary biologists, but so far there has been no comparison of biosynthetic pathways leading to a particular secondary metabolite in both prokaryotes and eukaryotes. We have detected the bioactive anthraquinone chrysophanol, which serves as a chemical defense in diverse eukaryotic organisms, in a bacterial Nocardia strain, thereby permitting the first comparative biosynthetic study. Two basic modes of folding a polyketide chain to fused-ring aromatic structures have so far been described: mode F (referring to fungi) and mode S (from Streptomyces). We have demonstrated that in eukaryotes (fungi, higher plants and insects), chrysophanol is formed via folding mode F. In actinomycetes, by contrast, the cyclization follows mode S. Thus, chrysophanol is the first polyketide synthase product that is built up by more than one polyketide folding mode. © 2006 Nature Publishing Group.

Publication metadata

Author(s): Bringmann G, Noll TF, Gulder TAM, Grune M, Dreyer M, Wilde C, Pankewitz F, Hilker M, Payne GD, Jones AL, Goodfellow M, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Nature Chemical Biology

Year: 2006

Volume: 2

Issue: 8

Pages: 429-433

ISSN (print): 1552-4450

ISSN (electronic): 1552-4469

Publisher: Nature Publishing Group


DOI: 10.1038/nchembio805

PubMed id: 16829953


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