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Soluble cell adhesion molecules in late-life depression

Lookup NU author(s): Professor Alan ThomasORCiD, Dr Christopher Morris, Dr Sue Davis, Professor John O'Brien


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Background: Late-life depression has been associated with vascular diseases and with increases in circulating cytokines and cell adhesion molecules in the prefrontal cortex. We hypothesized that soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) would be increased in late-life major depression. Methods: Serum levels of sICAM-1 and sVCAM-1 were measured in subjects over 60 with major depression (N = 23), subsyndromal depression (N = 20) and controls (N = 25). Depression severity was assessed using the Montgomery-Åsberg (MDRS) and Geriatric Depression (GDS) rating scales. Results: There was no significant increase in sICAM-1 (p = 0.240) or sVCAM-1 (p = 0.600) in depression nor was there any correlation of either molecule with depression severity. Adjusting for differences in cognitive impairment did not alter these findings. There was also no difference between subjects with an early onset of depression (before 60) and those with late-onset depression. Conclusions: These findings do not provide evidence that previously reported increases in serum cytokines in depression are due to peripheral vascular disease. Although we assessed subjects for vascular diseases it is possible that subtle but important differences between groups may still have been present and may have contributed to our negative findings. Our results suggest central nervous system mechanisms, such as related to HPA axis activation, may be responsible for the enhanced inflammatory response in depression. © 2007 International Psychogeriatric Association.

Publication metadata

Author(s): Thomas AJ, Morris C, Davis S, Jackson E, Harrison R, O'Brien JT

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2007

Volume: 19

Issue: 5

Pages: 914-920

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press


DOI: 10.1017/S1041610206004728

PubMed id: 17201994


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Funder referenceFunder name
G0400074Medical Research Council
G0502157Medical Research Council