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Urinary metabolites and health effects in workers exposed chronically to chloronitrobenzene

Lookup NU author(s): Dr Ovnair Sepai Adem BEM

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Abstract

For workers exposed to 4-chloronitrobenzene (4CNB), the major metabolites were determined. Urine were analysed before and after acid hydrolysis to qualify the free and conjugated metabolites of 4CNB. Three conjugated metabolites were identified in exposed workers: the mercapturic acid N-acetyl-S-(4-nitrophenyl)-L-cysteine (NANPC) was the only metabolite detected in non-hydrolysed urine, and accounted for approximately 51% of the total metabolites detected. The two remaining metabolites 4-chloroaniline (4CA) and 2-chloro-5-nitrophenol (CNP) were identified as cleavage products in hydrolysed urine, and accounted for approximately 18 and 30% of the total metabolites detected, respectively. No metabolites were found in factory controls within the limits of quantitation (LOQ) of the assay. There is a moderate correlation between NANPC and both 4CA and CNP. The correlation between 4CA and CNP is minor. The correlation between the total metabolites and both 4CA and CNP are good. The best correlation was found between the total metabolites and NANPC. There is a moderate inverse correlation between age and the creatinine levels. The raw metabolite levels CNP and NANPC decrease with age. 4CA, NANPC and the total metabolite levels correlate with the haemoglobin adduct levels. The urine metabolites increase and correlate significantly with the creatinine levels. NANPC is the most appropriate biomarker in the urine for a recent absorbed dose of 4CNB, since NANPC reflects the levels of 4CA and CNP and is the most prevalent metabolite detected in all the exposed workers.


Publication metadata

Author(s): Jones C, Sepai O, Liu Y-Y, Yan H, Sabbioni G

Publication type: Article

Publication status: Published

Journal: Biomarkers

Year: 2007

Volume: 12

Issue: 1

Pages: 1-20

Print publication date: 01/01/2007

ISSN (print): 1354-750X

ISSN (electronic): 1366-5804

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/13547500600799250

DOI: 10.1080/13547500600799250

PubMed id: 17438650


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