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Hydrogen Peroxide Sensing and Signaling

Lookup NU author(s): Dr Elizabeth Veal, Dr Alison Day, Professor Brian Morgan


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It is well established that oxidative stress is an important cause of cell damage associated with the initiation and progression of many diseases. Consequently, all air-living organisms contain antioxidant enzymes that limit oxidative stress by detoxifying reactive oxygen species, including hydrogen peroxide. However, in eukaryotes, hydrogen peroxide also has important roles as a signaling molecule in the regulation of a variety of biological processes. Here, we will discuss the molecular mechanisms by which hydrogen peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to hydrogen peroxide. © 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Veal EA, Day AM, Morgan BA

Publication type: Article

Publication status: Published

Journal: Molecular Cell

Year: 2007

Volume: 26

Issue: 1

Pages: 1-14

ISSN (print): 1097-2765

ISSN (electronic): 1097-4164

Publisher: Cell Press


DOI: 10.1016/j.molcel.2007.03.016

PubMed id: 17434122


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Funder referenceFunder name
G120/817Medical Research Council