Browse by author
Lookup NU author(s): Professor Jeff Errington FRS
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The clinically important vancomycin antibiotic inhibits the growth of pathogens such as Staphylococcus aureus by blocking cell wall synthesis through specific recognition of nascent peptidoglycan terminating in D-Ala-D-Ala. Here, we demonstrate the ability of single-molecule atomic force microscopy with antibiotic-modified tips to measure the specific binding forces of vancomycin and to map individual ligands on living bacteria. The single-molecule approach presented here provides new opportunities for understanding the binding mechanisms of antibiotics and for exploring the architecture of bacterial cell walls. © 2007 American Chemical Society.
Author(s): Gilbert Y, Deghorain M, Wang L, Xu B, Pollheimer PD, Gruber HJ, Errington J, Hallet B, Haulot X, Verbelen C, Hols P, Dufrene YF
Publication type: Article
Publication status: Published
Journal: Nano Letters
Print publication date: 01/03/2007
ISSN (print): 1530-6984
ISSN (electronic): 1530-6992
Publisher: American Chemical Society
PubMed id: 17316058
Altmetrics provided by Altmetric