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Lookup NU author(s): Professor Anne Dickinson
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Non-HLA genetics involving the study of single-nucleotide polymorphisms (SNPs) and microsatellites of cytokine and cytokine receptor genes, and as well as genes associated with response to infection and therapeutic drugs, are currently being studied for associations with diseases, including autoimmune disease, cancer and solid-organ transplant rejection. This chapter will summarize the potential role of non-HLA genetics in predicting outcome of haematopoietic stem-cell transplantation (HSCT) and how genotyping for non-HLA genes may give insight into the immunobiology of HSCT complications, including GvHD and infectious episodes. Future directions - including the role of pharmacogenomics, use of the research results for individualized medicine, and interpretation of data - will also be discussed. © 2006 Elsevier Ltd. All rights reserved.
Author(s): Dickinson AM
Publication type: Article
Publication status: Published
Journal: Best Practice and Research: Clinical Haematology
ISSN (print): 1521-6926
ISSN (electronic): 1532-1924
Publisher: Bailliere Tindall
PubMed id: 17448956
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