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Lookup NU author(s): Dr Lisa Ferguson,
Professor Mary Herbert
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The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes. © 2007 Nature Publishing Group.
Author(s): Kouznetsova A, Lister L, Nordenskjold M, Herbert M, Hoog C
Publication type: Article
Publication status: Published
Journal: Nature Genetics
Print publication date: 01/08/2007
ISSN (print): 1061-4036
ISSN (electronic): 1546-1718
Publisher: Nature Publishing Group
PubMed id: 17618286
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