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Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV)

Lookup NU author(s): Dr Janet Berrington, Dr Alan Fenton, Professor Andrew Cant, Dr Gavin Spickett, Dr Marilyn O'Keeffe, Professor John MatthewsORCiD


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A vaccine containing inactivated polio (eIPV) (Pediacel) is now used in the UK. The effect of the eIPV on other components is not well understood. We studied Haemophilus influenzae type b (Hib) and tetanus responses in preterm infants, <32 weeks gestation at birth, immunised with the (then) standard UK primary vaccines and either oral polio vaccine (OPV) or eIPV and analysed the effect showing reduced Hib responses with eIPV. © 2007 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Berrington JE, Fenton AC, Cant AJ, Spickett GP, O'Keeffe M, Matthews JNS

Publication type: Article

Publication status: Published

Journal: Vaccine

Year: 2007

Volume: 25

Issue: 49

Pages: 8206-8208

ISSN (print): 0264-410X

ISSN (electronic): 1873-2518

Publisher: Elsevier Ltd


DOI: 10.1016/j.vaccine.2007.09.060

PubMed id: 17977631


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