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Mechanotransduction of keratinocytes in culture and in the epidermis

Lookup NU author(s): Dr Julie Reichelt

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Abstract

The epidermis, like many other tissues, reacts to mechanical stress by increasing cell proliferation. Mechanically stressed skin regions often develop thicker skin and hyperkeratosis. Interestingly, a large number of skin diseases are accompanied by epidermal proliferation and hyperkeratosis even under normal mechanical stress conditions. Although, some of the molecular pathways of mechanical signaling involving integrins, the epidermal growth factor receptor and mitogen-activated protein kinases are known it is still unclear, how mechanical force is sensed and transformed into the molecular signals that induce cell proliferation. This review focuses on the molecules and pathways known to play a role in mechanotransduction in epidermal keratinocytes and discusses the pathways identified in other well-studied cell types. © 2007 Elsevier GmbH. All rights reserved.

Publication metadata

Author(s): Reichelt J

Publication type: Article

Publication status: Published

Journal: European Journal of Cell Biology

Year: 2007

Volume: 86

Issue: 11-12

Pages: 807-816

ISSN (print): 0171-9335

ISSN (electronic): 0724-5130

Publisher: Urban und Fischer Verlag

URL: http://dx.doi.org/10.1016/j.ejcb.2007.06.004

DOI: 10.1016/j.ejcb.2007.06.004

PubMed id: 17655967

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