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Lookup NU author(s): Dr Julia Reichelt
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The epidermis, like many other tissues, reacts to mechanical stress by increasing cell proliferation. Mechanically stressed skin regions often develop thicker skin and hyperkeratosis. Interestingly, a large number of skin diseases are accompanied by epidermal proliferation and hyperkeratosis even under normal mechanical stress conditions. Although, some of the molecular pathways of mechanical signaling involving integrins, the epidermal growth factor receptor and mitogen-activated protein kinases are known it is still unclear, how mechanical force is sensed and transformed into the molecular signals that induce cell proliferation. This review focuses on the molecules and pathways known to play a role in mechanotransduction in epidermal keratinocytes and discusses the pathways identified in other well-studied cell types. © 2007 Elsevier GmbH. All rights reserved.
Author(s): Reichelt J
Publication type: Article
Publication status: Published
Journal: European Journal of Cell Biology
ISSN (print): 0171-9335
ISSN (electronic): 0724-5130
Publisher: Urban und Fischer Verlag
PubMed id: 17655967
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