Browse by author
Lookup NU author(s): Dr Piers Cornelissen
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain. © 2007 Lippincott Williams & Wilkins, Inc.
Author(s): Kringelbach ML, Jenkinson N, Green AL, Owen SLF, Hansen PC, Cornelissen PL, Holliday IE, Stein J, Aziz TZ
Publication type: Article
Publication status: Published
Print publication date: 01/02/2007
ISSN (print): 0959-4965
ISSN (electronic): 1473-558X
Publisher: Lippincott Williams & Wilkins
PubMed id: 17314661
Altmetrics provided by Altmetric