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Neurocognitive function following remission in major depressive disorder: Potential objective marker of response?

Lookup NU author(s): Dr Peter Gallagher, Dr John Gray, Professor Allan Young, Dr Richard Porter

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Abstract

Objective: Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated. Method: A neurocognitive test battery was administered to unipolar depressed (major depressive disorder, MDD) patients (aged 18-65 years) who had been medication-free for at least 6 weeks, and to healthy controls. Patients were then treated according to clinical need, predominantly with standard pharmacotherapy, and all participants were followed up within 6 months. Results: Of the 25 MDD patients who returned at follow up, 11 were defined as remitted and 14 as not remitted. Significantly less baseline psychomotor dysfunction was observed in patients who remitted compared to those who did not (effect size, d =0.78, 95% confidence interval (CI) =0.07-1.44). Analysis of the change scores between assessments revealed a significantly greater improvement in verbal memory in patients who remitted compared to those who did not (d =0.73, 95%CI =0.03-1.39). Conclusions: This preliminary report suggests that there may be distinct temporal trajectories of neurocognitive improvement following remission in MDD. Aspects of neurocognitive functioning should be examined further as a means of providing a useful objective marker of treatment response.


Publication metadata

Author(s): Gallagher P, Robinson L, Gray J, Young A, Porter R

Publication type: Article

Publication status: Published

Journal: Australian and New Zealand Journal of Psychiatry

Year: 2007

Volume: 41

Issue: 1

Pages: 54-61

Print publication date: 01/01/2007

ISSN (print): 0004-8674

ISSN (electronic): 1440-1614

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/00048670601057734

DOI: 10.1080/00048670601057734

PubMed id: 17464681


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