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Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy Bodies and Alzheimer's disease

Lookup NU author(s): Dr Elise Rowan, Debbie LettORCiD, Professor John O'Brien, Professor Ian McKeith, Professor David BurnORCiD

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Abstract

Objective: We compared subjective sleep quality and excessive daytime somnolence (EDS) in controls, Parkinson's disease with (PDD) and without dementia (PD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We investigated whether sleep dysfunction and EDS associate with motor phenotype in PD, PDD and DLB. Method: Assessments included the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). Results: EDS was more frequent in PD, DLB and PDD patients than in AD. PDD, PD and DLB patients also had worse sleep quality when compared with AD and controls. Baseline postural instability-gait difficulty (PIGD) motor phenotype in PDD was associated with a higher ESS score and frequency of EDS, but this association was lost at two years. PSQI scores did not differ between PIGD dominant and non-dominant PD, PDD and DLB patients. Conclusion: EDS and poor sleep quality are greater in PD, PDD and DLB, compared with AD. The dissociation of EDS and motor phenotype suggests their pathophysiology is anatomically and/or temporally distinct. Copyright © 2006 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Boddy F, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2007

Volume: 22

Issue: 6

Pages: 529-535

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/gps.1709

DOI: 10.1002/gps.1709

PubMed id: 17096456

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