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Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients

Lookup NU author(s): Dr Stuart Watson, Dr Peter GallagherORCiD, Margaret Smith, Professor Allan Young, Emeritus Professor Nicol Ferrier


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The impact of lithium on arginine vasopressin (AVP) release has implications for our understanding of the pathophysiology and treatment of mood disorders and for the interpretation of neuroendocrine studies. In this secondary analysis of neuroendocrine, data from 23 patients with chronic major depressive disorder, 41 patients with bipolar disorder and 18 healthy controls, we examine the relationship between lithium therapy, AVP levels and the cortisol response to the dexamethasone/corticotropin-releasing hormone (dex/CRH) test. These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium. © 2007 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Watson S, Gallagher P, Smith MS, Young AH, Ferrier IN

Publication type: Article

Publication status: Published

Journal: Psychoneuroendocrinology

Year: 2007

Volume: 32

Issue: 5

Pages: 464-469

Print publication date: 01/06/2007

ISSN (print): 0306-4530

ISSN (electronic): 1873-3360

Publisher: Pergamon


DOI: 10.1016/j.psyneuen.2007.02.010

PubMed id: 17442500


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