Lookup NU author(s): Dr Stuart Watson,
Dr Peter Gallagher,
Professor Allan Young,
Professor Nicol Ferrier
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The impact of lithium on arginine vasopressin (AVP) release has implications for our understanding of the pathophysiology and treatment of mood disorders and for the interpretation of neuroendocrine studies. In this secondary analysis of neuroendocrine, data from 23 patients with chronic major depressive disorder, 41 patients with bipolar disorder and 18 healthy controls, we examine the relationship between lithium therapy, AVP levels and the cortisol response to the dexamethasone/corticotropin-releasing hormone (dex/CRH) test. These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium. © 2007 Elsevier Ltd. All rights reserved.
Author(s): Watson S, Gallagher P, Smith MS, Young AH, Ferrier IN
Publication type: Article
Publication status: Published
Print publication date: 01/06/2007
ISSN (print): 0306-4530
ISSN (electronic): 1873-3360
PubMed id: 17442500
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