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Lookup NU author(s): Dr Isam Salih,
Dr Ruben ThanacoodyORCiD,
Professor Simon ThomasORCiD
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We compared the effects of single doses of thioridazine and mesoridazine on the heart rate-corrected QT (QTc) interval in healthy adult volunteers. QTc intervals and plasma concentrations of thioridazine, mesoridazine, and metabolites were measured after single oral doses of thioridazine hydrochloride 50 mg, mesoridazine besylate 50 mg, or placebo in a double-blind, crossover study. Mean maximum increases in the QTc interval following thioridazine (37.3±4.1 ms, P=0.023) and mesoridazine (46.6±7.4 ms, P=0.021) were similar and significantly greater than following placebo (12.9±8.1 ms). The area under the effect-time curve over 8 h following drug administration was similar between the two drugs (129.3±22.1 vs 148.3±43.0 ms h). In conclusion, thioridazine and mesoridazine are associated with similar effects on the QTc interval.
Author(s): Salih ISM, Thanacoody RHK, McKay GA, Thomas SHL
Publication type: Article
Publication status: Published
Journal: Clinical Pharmacology and Therapeutics
Print publication date: 01/11/2007
ISSN (print): 0009-9236
ISSN (electronic): 1532-6535
Publisher: Nature Publishing Group
PubMed id: 17410120
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