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Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses

Lookup NU author(s): Dr Isam Salih, Dr Ruben Thanacoody, Professor Simon Thomas

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Abstract

We compared the effects of single doses of thioridazine and mesoridazine on the heart rate-corrected QT (QTc) interval in healthy adult volunteers. QTc intervals and plasma concentrations of thioridazine, mesoridazine, and metabolites were measured after single oral doses of thioridazine hydrochloride 50 mg, mesoridazine besylate 50 mg, or placebo in a double-blind, crossover study. Mean maximum increases in the QTc interval following thioridazine (37.3±4.1 ms, P=0.023) and mesoridazine (46.6±7.4 ms, P=0.021) were similar and significantly greater than following placebo (12.9±8.1 ms). The area under the effect-time curve over 8 h following drug administration was similar between the two drugs (129.3±22.1 vs 148.3±43.0 ms h). In conclusion, thioridazine and mesoridazine are associated with similar effects on the QTc interval.


Publication metadata

Author(s): Salih ISM, Thanacoody RHK, McKay GA, Thomas SHL

Publication type: Article

Publication status: Published

Journal: Clinical Pharmacology and Therapeutics

Year: 2007

Volume: 82

Issue: 5

Pages: 548-554

Print publication date: 01/11/2007

ISSN (print): 0009-9236

ISSN (electronic): 1532-6535

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.clpt.6100194

DOI: 10.1038/sj.clpt.6100194

PubMed id: 17410120


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