ePrints

Classical endocrine diseases causing obesity

Lookup NU author(s): Dr Jolanta Weaver

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism and polycystic ovarian syndrome to rare ones such as Cushing's syndrome, central hypothyroidism and hypothalamic disorders. The mechanisms for the development of obesity vary in according to the endocrine condition. Hypothyroidism is associated with accumulation of hyaluronic acid within various tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis. The pathophysiology of obesity associated with polycystic ovarian syndrome remains complex as obesity itself may simultaneously be the cause and the effect of the syndrome. Net excess of androgen appears to be pivotal in the development of central obesity. In Cushing's syndrome, an interaction with thyroid and growth hormones plays an important role in addition to an increased adipocyte differentiation and adipogenesis. This review also describes remaining rare cases: hypothalamic obesity due to central hypothyroidism and combined hormone deficiencies. Copyright © 2008 S. Karger AG.

Publication metadata

Author(s): Weaver J

Publication type: Article

Publication status: Published

Journal: Frontiers of Hormone Research

Year: 2008

Volume: 36

Pages: 212-228

ISSN (print): 03013073

ISSN (electronic): 1662-3762

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000115367

DOI: 10.1159/000115367

PubMed id: 18230905

Altmetrics

Share