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Anesthetic efficacy and pain induced by dental anesthesia: the influence of gender and menstrual cycle

Lookup NU author(s): Juliana Ramacciato, Dr John Meechan


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Objective: To assess the influence of the menstrual cycle and oral contraceptives on pain sensitivity and local anesthetic effectiveness. Study design: Thirty volunteers were designated into 3 groups (n = 10): group 1, women using contraceptives; group 2, women not using contraceptives; and group 3, men. Groups 1 and 2 had a buccal infiltration of 2% lidocaine with 1:100,000 epinephrine at the upper-right canine during each one of the 5 phases of the menstrual cycle and group 3 at a randomly selected day. Pain threshold, latency period, and pulpal anesthesia were measured with an electrical pulp tester. Injection discomfort was recorded. Data were analyzed with Friedman and Kruskal-Wallis tests. Results: Pain threshold was higher in men; however, there were no significant differences (P > .05) in anesthetic duration and injection discomfort. Conclusion: Injection discomfort and clinical effectiveness of local anesthetics are not related to sex, phases of the menstrual cycle, or use of oral contraceptives. © 2007 Mosby, Inc. All rights reserved.

Publication metadata

Author(s): Tofoli GR, Ramacciato JC, Volpato MC, Meechan JG, Ranali J, Groppo FC

Publication type: Article

Publication status: Published

Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Year: 2007

Volume: 103

Issue: 2

Pages: e34-e38

ISSN (print): 1079-2104

ISSN (electronic): 1528-395X

Publisher: Mosby, Inc.


DOI: 10.1016/j.tripleo.2006.08.024

PubMed id: 17095263


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