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Percutaneous Coronary Revascularization Reduces Plasma N-Terminal Pro-B-Type Natriuretic Peptide Concentration in Stable Coronary Artery Disease

Lookup NU author(s): Professor Azfar Zaman

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Abstract

Objectives: The purpose of this work was to assess the effect of percutaneous coronary revascularization (PCR) on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration. Background: Left ventricular (LV) dysfunction is associated with increased plasma natriuretic peptide concentrations. The effect of ischemia resolution on plasma natriuretic peptide is not known. Methods: Twenty-six patients with stable angina, normal LV systolic function, and isolated stenoses of the left anterior descending (LAD) coronary artery were studied. All patients had angiographically and physiologically significant lesions defined by cine-angiography and intracoronary pressure wire. Results: After revascularization, 24 patients demonstrated significant decrease in mean plasma NT-proBNP 8 weeks after PCR (from 177.2 ± 190.8 pg/ml to 105.0 ± 92.4 pg/ml, p = 0.03). The mean decrease in log NT-proBNP was 0.533, corresponding to geometric mean decrease of NT-proBNP by a factor of 59% (95% confidence interval 48.2% to 71.4%, p < 0.00005). Reduction in NT-proBNP was independent of change in LV systolic function. Conclusions: This study demonstrates that removal of fixed LAD stenosis reduces plasma NT-proBNP concentration. This has implications for interpretation of natriuretic peptide levels in clinical settings and as screening tool for LV systolic dysfunction. © 2007 American College of Cardiology Foundation.

Publication metadata

Author(s): McClure SJ, Gall S, Schechter CB, Kearney M, Zaman AG

Publication type: Article

Publication status: Published

Journal: Journal of the American College of Cardiology

Year: 2007

Volume: 49

Issue: 25

Pages: 2394-2397

ISSN (print): 0735-1097

ISSN (electronic): 1558-3597

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.jacc.2007.02.064

DOI: 10.1016/j.jacc.2007.02.064

PubMed id: 17599601

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