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Radical scavengers: A practical solution to the reproducibility issue in the fluoridation of diaryliodonium salts

Lookup NU author(s): Dr Michael Carroll, Dr Graham Smith

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Abstract

The addition of radical scavengers to the fluoridation of diaryliodonium salts was demonstrated to improve significantly both the reproducibility of the process and the material yield of the desired fluoroarene products. It was also established that the selectivity of the process was not influenced by the presence of the radical scavengers. TEMPO and galvinoxyl were found to be the most suitable radical scavengers in the fluoridation process allowing the methodology to be used routinely for the first time. © 2006.

Publication metadata

Author(s): Carroll MA, Nairne J, Smith G, Widdowson DA

Publication type: Article

Publication status: Published

Journal: Journal of Fluorine Chemistry

Year: 2007

Volume: 128

Issue: 2

Pages: 127-132

ISSN (print): 0022-1139

ISSN (electronic): 1873-3328

Publisher: Elsevier SA

URL: http://dx.doi.org/10.1016/j.jfluchem.2006.10.018

DOI: 10.1016/j.jfluchem.2006.10.018

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