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Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks

Lookup NU author(s): Dr Timothy Boswell


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Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are the members of the glucagon superfamily and bind to common receptors while PACAP also acts via the PACAP-specific receptor, PAC1. The aim of the present study was to investigate whether intracerebroventricular (ICV) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick. ICV injection of VIP did not significantly affect rectal temperature, but decreased energy expenditure. On the other hand, ICV injection of PACAP significantly increased both body temperature and energy expenditure. These specific actions of PACAP could be explained by an interaction with the PAC1 receptor, since they were partly, but not entirely, attenuated by PACAP (6-38), a PAC1 receptor antagonist. In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. This suggests that both peptides act centrally to regulate a catabolic response. In summary, brain VIP and PACAP both appear to exert generally catabolic effects on energy metabolism in the chick, but their influence on body temperature and glucose metabolism differs and their central effects do not appear to be mediated by the same receptors. © 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M

Publication type: Article

Publication status: Published

Journal: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Year: 2007

Volume: 147

Issue: 1

Pages: 156-164

Print publication date: 01/05/2007

ISSN (print): 1095-6433

ISSN (electronic): 1531-4332

Publisher: Elsevier Inc.


DOI: 10.1016/j.cbpa.2006.12.043

PubMed id: 17291802


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