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Lookup NU author(s): Dr Michael FirbankORCiD, Professor Andrew BlamireORCiD, Dr Andrew Teodorczuk, Dr Anil Gholkar OBE, Dr Roger Harrison, Professor John O'Brien
Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. We recruited 15 people with AD, 16 with DLB, and 15 healthy control subjects of similar age. They were scanned on a 1.5 T MRI system with diffusion tensor FLAIR imaging. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were calculated, and data were analysed using pre-defined regions of interest (ROI) and also with SPM. We found a significant decrease in the FA map in a ROI in the parietal lobe (precuneus) of the DLB group. Using SPM we found increased ADC in the left temporal lobe of AD subjects compared to controls. There were no other significant differences between groups. We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders. © 2007 Elsevier Ireland Ltd. All rights reserved.
Author(s): Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT
Publication type: Article
Publication status: Published
Journal: Psychiatry Research: Neuroimaging
Year: 2007
Volume: 155
Issue: 2
Pages: 135-145
Print publication date: 15/07/2007
Online publication date: 03/04/2007
Acceptance date: 14/01/2007
ISSN (print): 0925-4927
ISSN (electronic): 1872-7506
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.pscychresns.2007.01.001
DOI: 10.1016/j.pscychresns.2007.01.001
PubMed id: 17408930
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