Toggle Main Menu Toggle Search

Open Access padlockePrints

Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease

Lookup NU author(s): Dr Michael FirbankORCiD, Professor Andrew BlamireORCiD, Dr Andrew Teodorczuk, Dr Anil Gholkar OBE, Dr Roger Harrison, Professor John O'Brien



Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. We recruited 15 people with AD, 16 with DLB, and 15 healthy control subjects of similar age. They were scanned on a 1.5 T MRI system with diffusion tensor FLAIR imaging. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were calculated, and data were analysed using pre-defined regions of interest (ROI) and also with SPM. We found a significant decrease in the FA map in a ROI in the parietal lobe (precuneus) of the DLB group. Using SPM we found increased ADC in the left temporal lobe of AD subjects compared to controls. There were no other significant differences between groups. We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders. © 2007 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Psychiatry Research: Neuroimaging

Year: 2007

Volume: 155

Issue: 2

Pages: 135-145

Print publication date: 15/07/2007

Online publication date: 03/04/2007

Acceptance date: 14/01/2007

ISSN (print): 0925-4927

ISSN (electronic): 1872-7506

Publisher: Elsevier


DOI: 10.1016/j.pscychresns.2007.01.001

PubMed id: 17408930


Altmetrics provided by Altmetric


Funder referenceFunder name
G0400074Medical Research Council
G0502157Medical Research Council