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A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland

Lookup NU author(s): Professor Heather Cordell

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Abstract

Background: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles. Results: In addition to the evidence of linkage to the HLA region on 6p21 (nominal p = 4.0 × 10-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the HLA gave a maximum lod score (MLS) of 3.1 (nominal p = 2 × 10-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 × 10-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 × 10-3) on chromosome 18p11 under a general model. Conclusion: Our genome scan data confirmed the primary contribution of the HLA genes also in the high-risk Finnish population, and suggest that non-HLA genes also contribute to the familial clustering of type 1 diabetes in Finland. © 2007 Qiao et al; licensee BioMed Central Ltd.

Publication metadata

Author(s): Qiao Q, Osterholm A-M, He B, Pitkaniemi J, Cordell HJ, Sarti C, Kinnunen L, Tuomilehto-Wolf E, Tryggvason K, Tuomilehto J

Publication type: Article

Publication status: Published

Journal: BMC Genetics

Year: 2007

Volume: 8

Pages: -

Date deposited: 22/02/2010

ISSN (print): 1471-2156

ISSN (electronic):

Publisher: BioMed Central Ltd.

URL: http://dx.doi.org/10.1186/1471-2156-8-84

DOI: 10.1186/1471-2156-8-84

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