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Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children

Lookup NU author(s): Emerita Professor Anne Maguire, Dr Wasim Baqir

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Abstract

Objective. The reduced use of sugars-containing (SC) liquid medicines has increased the use of other dose forms, potentially resulting in more widespread dental effects, including tooth wear. The aim of this study was to assess the erosive potential of 97 paediatric medicines in vitro. Methods. The study took the form of in vitro measurement of endogenous pH and titratable acidity (mmol). Endogenous pH was measured using a pH meter, followed by titration to pH 7.0 with 0.1-m NaOH. Results. Overall, 55 (57%) formulations had an endogenous pH of < 5.5. The mean (± SD) endogenous pH and titratable acidity for 41 SC formulations were 5.26 ± 1.30 and 0.139 ± 0.133 mmol, respectively; for 56 sugars-free (SF) formulations, these figures were 5.73 ± 1.53 and 0.413 ± 1.50 mmol (P > 0.05). Compared with their SC bioequivalents, eight SF medicines showed no significant differences for pH or titratable acidity, while 15 higher-strength medicines showed lower pH (P = 0.035) and greater titratable acidity (P = 0.016) than their lower-strength equivalents. Chewable and dispersible tablets (P < 0.001), gastrointestinal medicines (P = 0.002) and antibiotics (P = 0.007) were significant predictors of higher pH. In contrast, effervescent tablets (P < 0.001), and nutrition and blood preparations (P = 0.021) were significant predictors of higher titratable acidity. Conclusions. Paediatric SF medicines were not more erosive than SC medicines in vitro; a more significant predictor of their erosive potential was dose form. © 2007 The AuthorsJournal compilation © 2007 BSPD, IAPD and Blackwell Publishing Ltd.


Publication metadata

Author(s): Maguire A, Baqir W, Nunn JH

Publication type: Article

Publication status: Published

Journal: International Journal of Paediatric Dentistry

Year: 2007

Volume: 17

Issue: 4

Pages: 231-238

ISSN (print): 0960-7439

ISSN (electronic): 1365-263X

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/j.1365-263X.2007.00826.x

DOI: 10.1111/j.1365-263X.2007.00826.x

PubMed id: 17559449


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