Browse by author
Lookup NU author(s): Professor Marco Carrozzo
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Cytokine polymorphisms may influence both the risk of developing oral lichen planus (OLP) and the outcome of hepatitis C virus (HCV)-infected patients and OLP has been frequently associated with HCV infection. The aim of the present study was to analyse whether cytokine polymorphisms may influence the susceptibility to HCV-related OLP. Thirty-five patients with OLP and chronic HCV infection (OLP-HCV+ve) took part in the study. As controls, 44 patients with OLP but without HCV (OLP-HCV-ve) infection and 140 healthy donors were studied. Thirteen cytokine genes with 22 single nucleotide polymorphisms (SNP) were studied. IFN-γ UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP-HCV+ve patients compared with OLP-HCV-ve that approached the statistical significance [P = 0.03, P-corrected (PC) = 0.66]. Contrarily, in OLP-HCV+ve patients, the frequency of genotype -308 G/A of the TNF-α was decreased, whereas the genotype -308 G/G was increased compared with OLP-HCV-ve (P = 0.0005, PC = 0.011 and P = 0.0016, PC = 0.0352, respectively). OLP patients with and without HCV infection showed a different genetic cytokine background suggesting distinct pathogenetic mechanisms. © 2007 The Authors Journal compilation 2007 Blackwell Munksgaard.
Author(s): Carrozzo M, Dametto E, Fasano ME, Arduino P, Bertolusso G, de Capei FU, Rendine S, Amoroso A
Publication type: Article
Publication status: Published
Journal: Experimental Dermatology
ISSN (print): 0906-6705
ISSN (electronic): 1600-0625
PubMed id: 17697145
Altmetrics provided by Altmetric