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Cytokine gene polymorphisms in hepatitis C virus-related oral lichen planus

Lookup NU author(s): Professor Marco Carrozzo


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Cytokine polymorphisms may influence both the risk of developing oral lichen planus (OLP) and the outcome of hepatitis C virus (HCV)-infected patients and OLP has been frequently associated with HCV infection. The aim of the present study was to analyse whether cytokine polymorphisms may influence the susceptibility to HCV-related OLP. Thirty-five patients with OLP and chronic HCV infection (OLP-HCV+ve) took part in the study. As controls, 44 patients with OLP but without HCV (OLP-HCV-ve) infection and 140 healthy donors were studied. Thirteen cytokine genes with 22 single nucleotide polymorphisms (SNP) were studied. IFN-γ UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP-HCV+ve patients compared with OLP-HCV-ve that approached the statistical significance [P = 0.03, P-corrected (PC) = 0.66]. Contrarily, in OLP-HCV+ve patients, the frequency of genotype -308 G/A of the TNF-α was decreased, whereas the genotype -308 G/G was increased compared with OLP-HCV-ve (P = 0.0005, PC = 0.011 and P = 0.0016, PC = 0.0352, respectively). OLP patients with and without HCV infection showed a different genetic cytokine background suggesting distinct pathogenetic mechanisms. © 2007 The Authors Journal compilation 2007 Blackwell Munksgaard.

Publication metadata

Author(s): Carrozzo M, Dametto E, Fasano ME, Arduino P, Bertolusso G, de Capei FU, Rendine S, Amoroso A

Publication type: Article

Publication status: Published

Journal: Experimental Dermatology

Year: 2007

Volume: 16

Issue: 9

Pages: 730-736

ISSN (print): 0906-6705

ISSN (electronic): 1600-0625

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1600-0625.2007.00577.x

PubMed id: 17697145


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