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Correlation between finger-prick and venous ciclosporin levels: Association with gingival overgrowth and hypertrichosis

Lookup NU author(s): Dr Malcolm Coulthard, Professor Janice EllisORCiD

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Abstract

The aims of this study were (1) to ascertain ciclosporin C2 levels currently being achieved in children with steroid-sensitive nephrotic syndrome (SSNS) and renal transplants (RTs), (2) to determine the feasibility of the use of finger-prick samples for the measurement of ciclosporin levels, and (3) to identify any correlation between hypertrichosis or gingival overgrowth (GO) and level of ciclosporin 2 h post-dose (C2). Seventy-two children (39 with SSNS, 33 with RT) participated. Ciclosporin 12 h trough (C12) and C2 levels were measured in venous and finger-prick samples by high-performance liquid chromatography tandem mass spectroscopy. Photographs of the teeth and back were taken for assessment of GO and hypertrichosis. Mean (±SD) C2 levels in the SSNS and RT groups were 512 (±181) μg/l and 471 (±229) μg/l. There was a highly significant relationship between venous and finger-prick ciclosporin levels (r2 = 0.96, P < 0.0001). Fourteen children had severe GO. There was a small, though statistically significant, impact of ciclosporin level on GO (C2 r2 = 0.12, P = 0.003 and C12 r2 = 0.06, P = 0.038) but no correlation with dose (milligrammes per kilogramme per day or milligrammes per square metre per day) or duration. Seventeen children had moderate or severe hypertrichosis, this being more common in children of South Asian ethnicity (P < 0.0001). There was no correlation between ciclosporin exposure or duration and hypertrichosis. Finger-prick blood sampling may serve as a practical alternative to venepuncture in children receiving ciclosporin. © IPNA 2007.

Publication metadata

Author(s): Webb NJA, Coulthard MG, Trompeter RS, Fitzpatrick MM, Stephens S, Dudley J, Maxwell H, Waller S, Smith GC, Watson AR, Hughes DA, Keevil BG, Ellis JS

Publication type: Article

Publication status: Published

Journal: Pediatric Nephrology

Year: 2007

Volume: 22

Issue: 12

Pages: 2111-2118

Print publication date: 01/12/2007

ISSN (print): 0931-041X

ISSN (electronic): 1432-198X

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00467-007-0586-z

DOI: 10.1007/s00467-007-0586-z

PubMed id: 17899211

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