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Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Lookup NU author(s): Dr Amy Reeve, Emeritus Professor Doug Turnbull


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A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. ┬ęThe Authors.

Publication metadata

Author(s): Krishnan KJ, Reeve AK, Turnbull DM

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: Focus Topics at Life Sciences

Year of Conference: 2007

Pages: 1232-1235

ISSN: 0300-5127

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0351232

PubMed id: 17956320

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752